Background:
Nephrotic syndrome is a common childhood renal disorder; the prevalence of Urinary
tract infection (UTI) in these patients is high. The increased prevalence of UTI are due to
immunoglobulin loss, defective T cell function, presence of ascites and relative malnutrition.
Objective:
The study is to evaluate the prevalence of UTI , its etiological agents, antibiotics, sensitivity
pattern and the outcome in children with nephrotic syndrome.
Methods:
A prospective study of all patients with diagnosis of nephrotic syndrome from January 2003
to December 2006. Urine specimen were routinely obtained by clean catch method following careful
preparation urethral orifices. The specimens were processed immediately. Five millimeters (5mml)
loopful of the sample were inoculated on a blood agar and CLED agar plates. Identification of the
organism to species level was by using stokes disc diffusion technique.
Results:
Forty two patients were studied. The mean age and SEM for males was 8.2 + 0.5years and
females with 7.9 + 0.8years. The age range was two to fifteen years UTI was caused predominantly by
Staphylococcus aureus
in 67.9%,
Klebsiella
species (17.9%) and
Pseudomonas
(14.2%). There was high
invitro resistance of these organisms to nalidixic acid and ampicillin but sensitive to cefotaxime,
ceftriazone and ciprofloxacin.
Conclusion:
It is recommend that UTI should be sought for in patients with nephrotic syndrome and
treatment should be prompt and appropriate.