Australasian Biotechnology,
Volume 8 Number 2, March/April 1998, pp. 96-98
Diversified Prime and Boost Protocols: The Route to
Enhanced Immune
Responses to Recombinant DNA Based Vaccines?
By Dr. David B. Boyle,
Code Number:AU98018
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Practically useful vaccination procedures may require both
an initial priming
exposure to
antigen, plus an additional boosting exposure. Diversified "prime
and boost protocols"
provide a means of generating elevated immune responses and
extending the duration of
immunity for new generation vaccines based on recombinant DNA
expressed antigens (as
subunit antigens, vector based or naked DNA). Enhanced responses
have been observed for
viral, parasite and cancer vaccines. In any vaccine study an
evaluation of diversified prime
and boost protocols is warranted. The immunological mechanisms
responsible for the
elevated responses have not been defined. A detailed
investigation of the mechanisms is
needed.
Copyright 1998 Australian Biotechnology Association Ltd.
