Well water is the only source of drinking water in Oproama Town in Rivers state, Nigeria. Water from these sources is consumed without treatment, and potentially poses a health risk to the local population. The Enterotoxigenicity profile of
Escherichia coli
,
Vibrio
and
Salmonella
species isolated from well and river water sources in Oproama were investigated using fluid accumulation (FA) ratio. The study revealed that Salmonella isolate (S9) from the river showed doubtful toxicity out of the ten
Escherichia coli, ten
Vibrio and ten Salmonella isolates. This study revealed a near-absence of enterotoxigenic
Escherichia coli,
Vibrio and Salmonella organisms from the waters in Oproama. More studies are required to further test the overall safety of these water sources due to the potential risk of consuming untreated water.