Evaluation of selected trace metals in some hypertensive subjects in a tertiary health institution in Southwest Nigeria.|
Onuegbu, Anaelechi J.; Ayodele, Olugbenga E.; Ayelagbe, Olubunmi G.; Olisekodiaka, Madu J.; Abiola, Rasheeda A.; Amah, Ubuo K. & Ukeh, Isaac L.
Published reports on the possible roles of trace metals in the aetiology of primary hypertension have
not been consistent. This study investigated the possible aetiological role of zinc (Zn), manganese (Mn), copper (Cu)
and selenium (Se) in primary hypertension. Atomic absorption spectrophotometry (AAS) was used to determine the
serum levels of Zn, Cu, Mn and Se in 45 patients with primary hypertension (stage I and stage II) and 47 apparently
healthy control subjects (normotensives and pre-hypertensives). Both patients and control subjects were classified
based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment
of High Blood Pressure (JNC 7). The weight, height and blood pressure of all subjects were measured and their
body mass indices (BMI) computed. The mean serum zinc concentration was significantly higher in the patients with
hypertension than in the control subjects (135.78 ± 9.10 vs 130.80 ± 12.50 μg/ml, p = 0.032). However, serum levels of
copper (68.16 ± 3.72 vs 68.53 ± 5.33 μg/dl, p = 0.697), manganese (63.11 ± 4.40 vs 62.87 ± 4.59 μg/dl, p = 0.800) and
selenium (75.91 ± 5.66 vs 78.13 ± 5.92 μg/L, p = 0.070) were not statistically different between the patients and the
control subjects. This study did not show any gender-, age- or obesity-related differences in serum level of zinc,
copper, manganese and selenium. Elevated level of serum zinc may play an aetiological role in subjects with
primary hypertension. However, further studies will be necessary to define the roles of trace elements in the
aetiology of primary hypertension in these individuals.
hypertension; zinc; manganese; copper; selenium.