The effect of 5% and 10% dietary incorporation of leaves of
Vernonia amygdalina
(VA) on oral glucose
tolerance was studied in normoglycemic male albino rats. The feeding of the vegetable incorporated diets (5% VA
and 10%VA) resulted in marked improvement in oral glucose tolerance in rats. After one week of diet administration,
following an oral glucose load (3g/kg body weight), blood glucose concentration (BGC) (mg/dL) in rats fed the 5%
VA peaked at 15minutes (147.24± 18.46), while the BGC in rats fed the control diet and 10% VA peaked at 30mins
(180.00 ± 28.57 and 159.48 ± 16.07 respectively). After two weeks of feeding of the vegetable incorporated diets, post
administration BGC peaked at 15 minutes in the test groups [5% VA diet (152.64± 33.46) and 10% VA diet group
(121.95± 24.78)] while the peak remained at 30 minutes in the control group. After 3 weeks of diet administration
BGC remained peaked at 15 minutes in the 5% and 10% VA diet groups (137.16 ± 61.29 and 132.75 ± 8.86
respectively). Rats in both test groups, after 3 weeks on the test diets, had their glycaemic indices reduced by 15-
18%. These findings indicate that feeding on diets containing
Vernonia amygdalina could positively modulate oral
glucose tolerance. The vegetable could be useful in dietary management of conditions associated with oral glucose
tolerance, and by extension, hyperglycemia.
