BioSafety, Volume 3, Paper 6 (BY97006) 1997
Online Journal - URL: http://www.bdt.org.br/bioline/by
Safety evaluation of transgenic potatoes transformed with synthetic
antibacterial peptide gene - toxicological test
WANG Ying, QIU Jinsong, SUN Yibin, QU Xianming, TANG Yixiong, JIA
Shirong
Code Number: BY97006
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SUMMARY
Cecropin B is an antibacterial peptide commonly existing in the insect
immune system. During the past decade, we have designed and synthesized
various novel antibacterial peptides and corresponding genes, such as
modified Cecropin B, Shiva A and Shiva 2A (an analog of Cecropin B with 40%
of amino acid sequence homology) and WHD. 3 clones with significant
enhanced resistance to bacterial wilt (caused by Pseudomonas solanacearum)
have been obtained. As part of the biosafety assessment of the transgenic
potato, here we report the results of toxicological tests obtained using
the synthetic peptide Shiva 2A. The acute toxicity study used the Ames,
micronucleus and chromosome aberration tests together with accumulative
toxicity to mice.
Keywords: release GMO
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Published by Bioline Publications
