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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482 EISSN: 0973-1482
Vol. 6, No. 4, 2010, pp. 546-548
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Bioline Code: cr10134
Full paper language: English
Document type: Case Report
Document available free of charge
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Journal of Cancer Research and Therapeutics, Vol. 6, No. 4, 2010, pp. 546-548
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Interstitial lung disease associated with FOLFOX chemotherapy
Lim, Joo Han; Kim, Hoon; Choi, Woong Gil & Lee, Moon Hee
Abstract
Currently, FOLFOX regimen has been widely used as an effective approach for treating many advanced GI tract cancers. Toxicity induced by oxaliplatin has been well known and mostly moderate and manageable. Gastrointestinal, hematological and neurosensory toxicities are the most common. However, information concerning the pulmonary toxicity of this regimen is very limited and only a few cases of severe lung toxicity associated with FOLFOX chemotherapy have been reported. Here, we report a fatal case of interstitial lung disease which was associated with FOLFOX chemotherapy in metastatic advanced gastric cancer. The patient expired from progressive respiratory failure. This case suggests that FOLFOX-induced interstitial lung disease should be considered in the differential diagnosis of new lung lesions in patients who are treated with FOLFOX chemotherapy. And further investigations of possible association that may lead to acute respiratory failure are warranted.
Keywords
FOLFOX, gastric cancer, interstitial lung disease
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© Copyright 2010 Journal of Cancer Research and Therapeutics. Alternative site location: http://www.cancerjournal.net/
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