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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482 EISSN: 0973-1482
Vol. 7, No. 3, 2011, pp. 251-255
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Bioline Code: cr11067
Full paper language: English
Document type: Review Article
Document available free of charge
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Journal of Cancer Research and Therapeutics, Vol. 7, No. 3, 2011, pp. 251-255
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Human papilloma virus: A new risk factor in a subset of head and neck cancers
Bisht, Manisha & Bist, Sampan Singh.
Abstract
Head and neck cancer is the sixth most common malignancy worldwide. Tobacco smoking and alcohol consumption are two well known behavioral risk factors associated with head and neck cancer. Recently, evidence is mounting that infection with human papilloma virus, most commonly human papilloma virus-16 is responsible for a subset of head and neck squamous cell carcinoma especially tumors of tonsillar origin. The molecular pathway used by human papilloma virus to trigger malignant transformation of tissue is different from that of other well known risk factors, i.e. smoking and alcohol, associated with squamous cell carcinoma. Apparently, these subsets of patients with human papilloma virus positive tumor are more likely to have a better prognosis than human papilloma virus negative tumor. Considering this fact, the human papilloma virus infection should be determined in all oropharyngeal cancers since it can have a major impact on the decision making process of the treatment.
Keywords
Human papilloma virus, oropharyngeal carcinoma, squamous cell carcinoma
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© Copyright 2011 Journal of Cancer Research and Therapeutics. Alternative site location: http://www.cancerjournal.net/
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