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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0378-6323
Vol. 71, No. 6, 2005, pp. 398-400
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Bioline Code: dv05132
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Dermatology, Venereology and Leprology, Vol. 71, No. 6, 2005, pp. 398-400
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Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: An open uncontrolled study
Mangla Kanu, Rastogi Swati, Goyal Puneet, Solanki RekhaB, C Ranjan
Abstract
Background: High dose intravenous immunoglobulins (IVIG) have emerged as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies support the view that IVIG can block the fas-fas ligand mediated apoptosis in TEN.
Methods: Ten pediatric patients of TEN were treated with IVIG (0.05 - 0.1 gm/kg/day) along with antibiotics and supportive care.
Results: Patients with 67% of mean body surface area of involvement showed an average of 2.1 days for arrest of progression of lesions and 8.1 days for complete reepithelization. There was no mortality.
Conclusions: Low dose IVIG appears to be a safe and effective treatment for TEN in children. Randomized trials are needed to further evaluate the efficacy of IVIG and compare it with other therapeutic modalities.
Keywords
Toxic epidermal necrolysis, Intravenous immunoglobulins
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© Copyright 2005 Indian Journal of Dermatology, Venereology and Leprology. Alternative site location: http://www.ijdvl.com
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