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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0378-6323
Vol. 77, No. 5, 2011, pp. 594-596
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Bioline Code: dv11172
Full paper language: English
Document type: Case Report
Document available free of charge
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Indian Journal of Dermatology, Venereology and Leprology, Vol. 77, No. 5, 2011, pp. 594-596
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Multiple isolated cutaneous plexiform schwannomas
Attia, Enas A. S.; Yassin, Marwa; Lasheen, Mohamed A.; Salem, Samar Abdalla & Khafagy, Naziha H.
Abstract
Plexiform schwannoma is a rare neurogenic tumor, arising from skin and subcutaneous
tissue. The presence of multiple schwannomas suggests a possible association with
neurofibromatosis type 2 (NF2). A 50-year old male patient presented with multiple papulonodular
cutaneous lesions on both arms and forearms. Histopathological examination
revealed a dermal multinodular pattern of well-circumscribed masses of closely packed
cells, with peripheral myxoid tissue, well-encapsulated in a thin collagenous capsule. S-100
immunohistochemical staining was diffusely and strongly positive. Neuron-specific enolase
was positive, confirming a neural tissue tumor. An audiogram and Magnetic Resonance
Imaging (MRI) of cerebro-pontine angle showed no detected abnormality, excluding
acoustic neuroma. Thus, we present a case of multiple bilateral isolated cutaneous plexiform
schwannomas, not associated with NF2. Multiple plexiform schwannomas is a very rare
entity, distinct from neurofibromatosis (NF), and being confined to the dermis is even more
rarely reported.
Keywords
Neurofibromatosis, plexiform, schwannoma
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