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Novel antiviral activity of dialdehyde starch
Song, L.; Cruz, C.; Farrah, S.R. & Baney, R.H.
Abstract
A significant effort worldwide is being directed toward
development of novel biocides against drug-resistant
bacterial and viruses because of the significant potential
human infection risks in the general population. We
report here the discovery of a strong antiviral biocide,
dialdheyde starch (DAS). Antiviral tests were carried
out against three non-envelop viruses, including two
bacterial viruses MS2 and PRD1, and one human virus
Poliovirus. Dialdehyde starch aqueous suspensions were
effective biocides against these three test viruses in a 1
hr exposure test. The antiviral activity was significantly
enhanced in a four-hour exposure test, with maximum
seven orders of magnitude reductions against MS2 and
PRD1, and four-order reduction against Poliovirus. The
antiviral activity of dialdehyde starch was found to be
pH dependent, being more active in alkaline and acidic
conditions than in neutral conditions.
Keywords
antiviral, biocide, dialdehyde starch, virus
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