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The Journal of Health, Population and Nutrition
icddr,b
ISSN: 1606-0997 EISSN: 1606-0997
Vol. 33, No. 2, 2015, pp. 1-8
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Bioline Code: hn15035
Full paper language: English
Document type: Research Article
Document available free of charge
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The Journal of Health, Population and Nutrition, Vol. 33, No. 2, 2015, pp. 1-8
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Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial
Dolatkhah, Neda; Hajifaraji, Majid; Abbasalizadeh, Fatemeh; Aghamohammadzadeh, Naser; Mehrabi, Yadollah & Abbasi, Mehran Mesgari
Abstract
Background: Although several studies have found probiotics encouraging in prevention of gestational diabetes
mellitus (GDM), the evidence for the use of probiotics in diagnosed GDM is largely limited. The aim of this study
was to assess the effect of a probiotic supplement capsule containing four bacterial strains on glucose metabolism
indices and weight changes in women with newly diagnosed GDM.
Methods: Sixty-four pregnant women with GDM were enrolled into a double-blind placebo-controlled randomized
clinical trial. They were randomly assigned to receive either a probiotic or placebo capsule along with dietary
advice for eight consecutive weeks. The trend of weight gain along with glucose metabolism indices was assayed.
Results: During the first 6 weeks of the study, the weight gain trend was similar between the groups. However, in
the last 2 weeks of the study, the weight gain in the probiotic group was significantly lower than in the placebo
group (p < 0.05). Fasting blood sugar (FBS) decreased in both intervention (from 103.7 to 88.4 mg/dl) and control
(from 100.9 to 93.6 mg/dl) groups significantly, and the decrease in the probiotic group was significantly higher
than in the placebo group (p < 0.05). Insulin resistance index in the probiotic group had 6.74 % reduction over the
study period (p < 0.05). In the placebo group, however, there was an increase in insulin resistance index (6.45 %),
but the observed change in insulin resistance was not statistically significant. Insulin sensitivity index was increased
in both groups. The post-intervention insulin sensitivity index in the probiotic group was not significantly different
from placebo when adjusted for the baseline levels.
Conclusions: The probiotic supplement appeared to affect glucose metabolism and weight gain among pregnant
women with GDM. This needs to be confirmed in other settings before a therapeutic value could be approved.
Keywords
Probiotics; Gestational diabetes mellitus; Nutrition; Randomized clinical trial
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