The acute Toxicological effects of Gammalin 20 on the lung and Pancreas of Guinea Pig

The acute toxicological effects of Gammalin 20 (gamma Isomer of hexachlorocyclohexane) on the lungs and Pancreas of Guinea Pig were investigated. Twenty-Eight Guinea Pigs of 300gm average body wt were used for the study. Five dose levels 0.0gkg., 0.82gkg^-1., 1.63gkg^-1., 3.25gkg^-1 and 6.5gkg^-1 were obtained after a range finding test using five guinea pigs and administered intra peritoneally, into the animals. Signs and symptoms of toxicity (Irritability, staggering, laboured breathing, convulsion and death) were observed, scored in this order of severity and found to be dose dependent. Histopathological examination of the lungs revealed edema, congestion and disruption of lung architecture. The Pancreas showed acute toxic inflammatory reaction, edema, acute pancreatitis and disruption of Pancreatic architecture. LD₅₀ of gammalin 20 in the male guinea pig using intraperitoneal route was 1.87gkg^-1. gammalin 20 therefore based on classification of toxicity of chemicals was found to be slightly toxic to the male guinea pig using intraperitoneal route of administration. @JASEM