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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 21, No. 3, 2017, pp. 504-508
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Bioline Code: ja17054
Full paper language: English
Document type: Study
Document available free of charge
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Journal of Applied Sciences and Environmental Management, Vol. 21, No. 3, 2017, pp. 504-508
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Protective Effects of Aqueous Extract of Cinnamon on Diabetes-Induced Nephrotoxicity in Wistar Rats
ODIASE, DE & OM’INIABOHS, FAE
Abstract
Diabetes mellitus is a chronic metabolic disorder with multi-systemic adverse
effects on the body. Cinnamon is atraditional folk herbsused for treatment of diseases and was
popularas an embalming agent. The present study was undertaken to evaluate the effect of
crude aqueous extract of Cinnamon for its protective activities on diabetes-induced
nephrotoxicity in Wistarrats. Twenty-four adult Wistar rats of both sexes were assigned to three
groups containing eight rats (n=8). Group A was the control group, group B was the
streptozotocin-treated group, and group C was the streptozotocin followed by crude aqueous
extract of Cinnamon treated group. Group B received 50mg/kg of STZ by the intraperitoneal
(i.p.) injection. Group C received 50 mg/kg of STZ i.p. and 300 mg/kg/day of the aqueous
extract of Cinnamon for 21 days. All the rats including the control group were fed with
commercially formulated feeds and water ad`libidum for the same number of days.Effect of
concurrent oral administration of crudeaqueous extract of Cinnamon at a dose of 300 mg/kg/day
on the renal integrity was determined using serum creatinine, blood urea as indicators of kidney
damage supporting histopathological findings. It was observed that the crude aqueous extract of
Cinnamon significantly protect rat kidneys from diabetes-induced histopathological changes.
This extract also normalized the increase in serumcreatinine and blood urea that characterized
the diabetic group of rats.In conclusion, administration of aqueous extract of Cinnamon protects
the kidneys of adult Wistar rats against diabetes-induced nephrotoxicity.
Keywords
Aqueous extract; Cinnamon; Histological; Nephrotoxicity; Streptozotocin(STZ); Integrity
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© Copyright 2017 - Journal of Applied Sciences and Environmental Management
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