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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 21, No. 4, 2017, pp. 673-679
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Bioline Code: ja17072
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Applied Sciences and Environmental Management, Vol. 21, No. 4, 2017, pp. 673-679
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Biochemical and Histological effects of Aqueous extract of Cyperus Esculentus in Triton Wr-1339 Induced Hyperglycemic Rats.
INNIH, SO; UBHENIN, AE & LAWAL, ET
Abstract
Researchers and physicians look forward to effective therapeutic agents possibly
from medicinal plants following the ineffectiveness of modern drugs used in the treatment of
fatty liver and its related diseases. To this ends, we evaluated the effect of Cyperus esculentus
on the liver in experimentally induced hyperlipidemia in rats.Aqueous extract of the plant was
administered orally to rats at the doses of 300,400 and 600mg/kg body weight(b.wt) for a period of
twenty nine days. Fatty liver was induced by twice intraperitoneal injection of TritonWR-1339
at a dose of 300mg/kg b.wt. to wistar rats . The result shows that administration of triton led to
significant (P˂0.05) serum increase in the activities of alanine and aspartate aminotransferases
(ALT and AST) of the rats.There was no significant (p˃0.05) change in the activities of serum
alkaline phosphatase following the administration of triton.The study also shows that there were
significant( p˂0.05) reduction in the serum level of total protein , albumin and globulin and
increase in serum level of total and conjugated bilirubin though not statistically significant
(p˃0.05) following the administration of triton to rats.The observed effects are suggestive of
mild toxicity of the liver by triton and this is further supported by several histopathological
manifestations such as hepatocellular degeneration, macrovesicular vacuolation,periportal
necrosis, congestion ,severe intimal ulceration and stenosis in the blood vessels . Treatment
with the aqueous extract of Cyperus esculentus attenuated both the biochemical effects and
histopathological manifestations.In conclusion, the results from the serum liver enzymes
biochemical parameters and histopathological analyses suggested the toxicity of triton and
also showed the effectiveness of the aqueous extract of Cyperus esculentus in attenuating the
liver toxicity .
Keywords
Cyperus esculentus; Triton,macrovesicular vacuolation; periportal necrosis
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© Copyright 2017 - Journal of Applied Sciences and Environmental Management
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