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Effect of Aqueous Allium Cepa Extract from Red Onion on Aluminum Chloride-Induced Anemia in Female Rats
IGE, SF & AIYEOLA, A
Abstract
This study examined the protective effect of Allium cepa extract from red onion on aluminum –
induced anemia in female wistar rats. Twenty-four animals (six rats per group) were used for this study. They were
divided into four groups: group one served as control, group two animals were treated with 100mg/kg BW of
aluminum chloride and served as Aluminum chloride (AlCl3) group, group three, Allium cepa alone group were
treated with 1mL/100g BW of Allium cepa while group four was simultaneously treated with 1mL/100g BW of
Allium cepa and 100mg/kg BW AlCl3. Treatments lasted for 4 weeks. Red blood cells (RBC), packed cell volume
(PCV), Hemoglobin concentration (Hb) were measured from blood sample collected from each rat. Serum urea,
serum and kidney malondialdehyde (index of lipid peroxidation) and kidney catalase and superoxide dismutase
(SOD) activities were measured spectrophotometrically. Significant decrease in RBC, PCV, Hb, catalase, SOD and
significant increase in serum urea and malondialdehyde were observed in aluminum treated animals when compared
with control. Animals treated with Allium cepa alone had significant increase in PCV, Hb, SOD and significant
decrease in malondialdehyde and serum urea while there was no significant different in RBC and catalase when
compared with control. Simultaneous treatment of the animals with Allium cepa and aluminum chloride resulted in
significant increase in PCV while there was no significant different in RBC, Hb, catalase, malondialdehyde when
compared with control.This study reveals that Allium cepa extract treatment ameliorate aluminum-induced anemia
through antioxidant system.
Keywords
Anemia; Allium cepa; Aluminum chloride; lipid peroxidation.
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