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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 24, No. 7, 2020, pp. 1137-1143
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Bioline Code: ja20166
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Applied Sciences and Environmental Management, Vol. 24, No. 7, 2020, pp. 1137-1143
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Evaluation of Stoichiometry, Stability Constants and Gibbs Free Energies of Acetaminophen-Zn (II) complex at Different Temperatures
IKPEAZU, OV; OTUOKERE, IE & IGWE, KK
Abstract
Acetaminophen also known as paracetamol, is a drug used in the treatment of pain and fever. It is
essentially used for the relief of mild to moderate pain. The presence of phenol and carbonyl oxygen atom enables
acetaminophen to behave as a bidentate ligand. The stoichiometry, stability constants and Gibbs free energies of
acetaminophen-Zn (II) were determined colorimetrically at 25 and 40 oC using continuous variation and mole ratio
methods. The formation of Zn (II) complex with acetaminophen was studied colorimetrically at an absorption maximum
of 630 nm at different temperatures. The data showed that Zn (II) and acetaminophen combine in the molar ratio of 1:1
at pH 7.4 with ionic strength maintained using 0.1M KNO3. Calculated stability constants values were 2.70 x 103 and 2.20
x 103 using continuous variation method and 7.21 x 103 and 7.21 x 103 using mole ratio methods at 25 and 40 oC respectively. Calculated ∆GƟ for the complex were - 1.96 x 104 and -1.98 x 104 J using continuous variation method and
-2.2 x 104 J and - 2.31 x 104 J using mole ratio method at 25 and 40 oC respectively. The stability constant and Gibbs
free energy results suggested that acetaminophen used in the study is a good chelating agent and can be an efficient
antidote in the therapy of Zn (II) overload or poisoning.
Keywords
Acetaminophen; Zinc; complex; stability constant; Gibbs free energy.
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© Copyright 2020 - Ikpaezu et al.
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