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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 48, No. 1, 2002, pp. 56-63
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Bioline Code: jp02019
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 48, No. 1, 2002, pp. 56-63
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Update Article - Allograft Biopsies in Management of Pancreas Transplant Recipients
Randhawa P
Abstract
Pancreatic transplantation is becoming increasingly accepted as a treatment modality for Type 1 diabetes mellitus. When allograft dysfunction is noted during follow up of patients, a biopsy is an extremely useful tool to diagnose various forms of rejection, and to rule out non-immunologic causes of graft malfunction, such as donor disease, ischaemic/preservation injury, vascular thrombosis, pancreatitis, post-transplant lymphoproliferative disease, technical complications and recurrence of diabetes mellitus. In addition to its role in establishing the primary diagnosis, a biopsy can grade the severity of pathology present, help determine the most appropriate therapy, and provide information relevant to graft prognosis.
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