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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 14, No. 1, 2007, pp. 4-9
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Bioline Code: mj07002
Full paper language: English
Document type: Research Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 14, No. 1, 2007, pp. 4-9
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GENETICS OF CLEFT LIP AND PALATE : A REVIEW
Rajion, Zainul Ahmad & Alwi, Zilfalil
Abstract
Orofacial clefts, particularly non-syndromic cleft lip with or without cleft palate
(CL/P) are the most common craniofacial deformities, affecting one in every 700
to 1000 newborns worldwide. Numerous efforts have been made to understand
the etiology of CL/P so as to predict its occurrence and to prevent it from occurring
in the future. In the recent years, advances in genetics and molecular biology have
begun to reveal the basis of craniofacial development. Various genetic approaches,
including genome-wide and candidate gene association studies as well as linkage
analysis, have been undertaken to identify aetiologic factors, but results have often
been inconclusive or contradictory. These results may support the presence of
aetiologic heterogeneity among populations and the presence of multiple genes
involved in the aetiology of CL/P. Despite these difficulties, several different genes
have been implicated in harbouring genes that contribute to the aetiology of CL/P.
In conclusion, the genetic basis of CL/P is still controversial because of genetic
complexity of clefting.
Keywords
Orofacial clefts, genetics, candidate genes
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© Copyright 2007 - Malaysian Journal of Medical Science Alternative site location: http://www.medic.usm.my/publication/mjms/
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