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Case Report - Choriocarcinoma with negative urinary and serum beta human chorionic gonadotropin (β HCG) : A case report Mehra Reeti, Huria Anju, Gupta Pratiksha, Mohan Harsh Abstract This was a rare case where a patient presented clinically as a case of post abortal sepsis and ultrasound showing the picture of an intramural degenerating fibroid. Her serum and urine both were negative for β human chorionic gonadotropin (βHCG). Patient succumbed to choriocarcinoma 1 month later. Failure to detect urinary and serum βHCG lead to maternal mortality due to the choriocarcinoma. The failure to detect, certain degradation products of HCG which may predominate in gestational trophoblastic neoplasia, by many common HCG testing kits lead to the error of diagnosis. Only 3 of the 7 common commercial serum HCG tests appropriately detects nicked HCG and its free βHCG, DPC immulite assay, being the most sensitive method. Though of rare occurrence, this awareness is important for diagnosis and follow-up of gestational trophoblastic neoplasia and could have been life saving in our case. Keywords Choriocarcinoma, b Human chorionic gonadotropin (bHCG) assays, Urine pregnancy test

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