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Acyclovir Induced Extrapyramidal Symptoms : Letter to Editor
S.K. Handa, C.P. Das, S. Prabhakar
Abstract
Acyclovir is usually a well tolerated antiherpetic agent. Vomiting and hypotension after intravenous administration and, occasionally, non-oliguric renal failure in dehydrated patients, are well known side effects.1-4 Confusion, hallucinations, seizures and coma are much rarer and have been reported in immunocompromised patients.4 Since there is a wide overlap of serum concentrations in patients with and without neurologic side effects, the relation between central nervous system effects and acyclovir serum concentrations remains unclear. Most of the cases of neurotoxicity with acyclovir have been described either with intravenous formulation, with or without preexisting renal disease, or with oral acyclovir formulation with end stage renal disease.2,4-6 A case of neurotoxicity following orally administered acyclovir in a young healthy girl with herpes labialis is described here.
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