|
Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 51, No. 3, 2003, pp. 367-369
|
Bioline Code: ni03119
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
|
Neurology India, Vol. 51, No. 3, 2003, pp. 367-369
| en |
Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy
Pandey GS , Kesari A, Mukherjee M, Mittal RD, Mittal B
Abstract
The reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present results implicate a need to reevaluate the reading frame hypothesis.
|
| |
© Copyright 2003 Neurology India. Online full text also at http://www.neurologyindia.com
Alternative site location: http://www.neurologyindia.com
|
|
