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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 17, No. 1-2, 2002, pp. 30-35
Bioline Code: np02006
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 17, No. 1-2, 2002, pp. 30-35

 en POTENT VASCOCONSTRICTION OF THE MESENTERIC VESSELS BY THE VENOM EXTRACT OF THE SEA ANEMONE, Tealia felina check for this species in other resources
KONYA, ROSELINE, S.

Abstract

Partially purified extract (extract IV) of the sea anemone, Tealia felina check for this species in other resources was shown to have a vasoconstrictor effect on the mesenteric vessels of the rat. The potent constriction by the extract was found to be dose-related Extract IV-induced responses on the mesenteric vessels were slow and long-lasting in contrast to the brief and short-lasting response of noradrenaline. Extract IV-induced responses rose slowly to a peak and lasted much longer after (time to peak = 2.5 min; duration =12min). This response of the extract was not blocked by α-blockers, as perfusion with indoramin (10-6M) and; phentolamine (10-7M) blocked the responses of noradrenaline (NA) but had no effect on the extract IV - induced vasoconstrictor responses. However, indomethacin (60μg/ml) blocked the responses to extract IV.

Keywords
Tealia felina, potent vasoconstriction, mesenteric vessels

 
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