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DEFFERENTIAL CITRATE CLEARANCE IN 2-KIDNEY, 1-CLIP RENOVASCULAR HYPERTENSION ODIGIE, P. I., AND ADIGUN, S. A. Abstract The systemic state of acid base balance exerts a dominant influence on renal citrate handling and rats with 2K-IC renovascular hypertension have been reported to exhibit a marked derangement in acid-base balance status. Citrate clearance was therefore investigated in the clipped and contralateral kidneys, I-Clip (2-K-IC) renovascular hypertensive rats, in order to determine to what extent deranged acid-base balance affect renal citrate handling. 2K-IC renovascular hypertension was induced in male SD rats (100 ± 5g) by clipping the left renal artery using a 0.2mm silver clip under ether anesthesia. Control rats were sham-operated. 2 weeks post renal artery clamping, the contralateral kidney of 2K-IC rats exhibited elevated fractional excretion of citrate (16.7 ± 6.30% vs. 1.70 ± 0.04%; P<0.01), which was sustained into the established stages of 2K-IC hypertension (10.2 ± 4.8% vs. 6.2 ± 1.30%; P<0.05 at 14 weeks). The fractional; excretion of citrate from the clipped kidney was not significantly different from those of controls. Since the excretion of a citrate ion is equivalent to loss of 3 bicarbonate ions, the enhanced citrate clearance of the contralateral kidney contributes to the metabolic acidosis associated with 2K-IC renovascular hypertension. Keywords Citrate Clearance-Goldblatt 2K-IC-Renovascular Hypertension-Acid-Base Balance

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