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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 23, No. 1-2, 2008, pp. 79-83
Bioline Code: np08016
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 23, No. 1-2, 2008, pp. 79-83

 en Methanolic Extract Of Tetracera potatoria check for this species in other resources , An Antiulcer Agent Increases Gastric Mucus Secretion And Endogenous Antioxidants
Oluwole, F. S.; Ayo, J. A.; Omolaso, B. O.; Emikpe, B. O. & Adesanwo, J. K.

Abstract

In this study, the possible mechanism underlying the antiulcer activity of the methanolic extract of the root of Tetracera potatoria check for this species in other resources (MeTp) was studied in albino rats. Misoprostol and omeprazole were used as reference drugs. The animals had MeTp administered to them at varying doses of 100, 400 and 800 mg/kg for 15 days. MeTp significantly (P<0.05) increased gastric mucus secretion and gastric mucus cell counts when compared to control. MeTp treated animals also showed significant (P<0.05) increase in the activity of superoxide dismutase (SOD) with concurrent decrease in the level of malonialdehyde (MDA) with respect to control. These findings suggest that part of the gastroprotective property of MeTp is associated with the ability of the extract to cause stimulation of gastric mucus secretion through increased number of gastric mucus cells. Increased SOD-activity and decreased MDA-levels further lend support to its gastroprotective effect.

Keywords
Tetracera potatoria, gastroprotective, gastric mucus secretion, superoxide dismutase

 
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