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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 24, No. 1, 2009, pp. 67-71
Bioline Code: np09011
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 24, No. 1, 2009, pp. 67-71

 en Aqueous Leaf Extract Of Rothmannia longiflora check for this species in other resources Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats
Ikpi, D. E.; Obembe, A. O.; Nku, C. O. & Awiwa, C.

Abstract

This study evaluated the action of aqueous leaf extract of Rothmannia longiflora check for this species in other resources on basal metabolic rate and electrolyte profile of alloxan-induced diabetic rats. Fifteen male Wistar (135 – 140g) were assigned to 3 groups of 5 rats each. Group 1 which served as control received placebo treatment; Group 2 - the diabetic (untreated) group also received placebo treatment whereas Group 3 – the extract treated diabetic group was administered the extract (15g/kg body weight) by oral administration for 14 days. Results of BMR measurement showed a significant increase (P<0.01) in BMR level of Diabetic untreated group (1.03±0.02ml/hr/g) when compared to the Control group (0.79±0.07ml/hr/g). Extract treatment significantly decreased (P<0.05) BMR in the diabetic rats. Results of analyses of serum electrolytes and glucose showed significant decreases (P<0.01) in sodium and chloride concentrations in the diabetic untreated group when compared to the control. However, sodium and chloride concentrations in the extract treated diabetic were not significantly different from those of their control values. There was no significant difference in potassium and urea concentrations in the extract-treated diabetic rats with respect to their control values. Extract treatment significantly reduced (P<0.05) serum glucose level of the extract treated group when compared to the diabetic untreated group. This suggests that oral administration of Rothmannia longiflora might be beneficial for the restoration of basal metabolic rate and the improvement of electrolyte profile in diabetes mellitus.

Keywords
Rothmannia longiflora, diabetes mellitus, basal metabolic rate, electrolytes

 
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