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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 24, No. 2, 2009, pp. 101-106
Bioline Code: np09017
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 24, No. 2, 2009, pp. 101-106

 en Comparative study of artesunate, ACTs and their combinants on the hormonal parameters of the male Guinea-pig
Obianime, A. W. & Aprioku, J. S.

Abstract

In this study, the effects of half, normal and double clinical doses of artesunate; artesunate/sulfadoxine/ pyrimethamine; artesunate/amodiaquine and their combinants (sulfadoxine/pyrimethamine and amodiaquine) on the basal serum levels of testosterone, FSH, LH and prolactin of the guinea-pig were investigated. The results of this study showed that the agents caused significant decreases (p<0.05) in serum testosterone level, with varying effects on LH, FSH and prolactin. Testosterone level was decreased by artesunate (37%), sulfadoxine/pyrimethamine (22%), amodiaquine (14%), artesunate/sulfadoxine/pyrimethamine (41%) and artesunate/amodiaquine (49%) at the clinical dose, compared to the serum levels in control animals. Furthermore, artesunate and amodiaquine also caused moderate decreases in the serum concentrations of LH and FSH, without an effect on prolactin. The effects of these agents may be due to oxidative stress on the reproductive system of the organism.

Keywords
Testosterone, ACTs, artesunate, hormones and Guinea pig

 
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