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Nigerian Journal of Physiological Sciences
Physiological Society of Nigeria
ISSN: 0794-859X
Vol. 24, No. 2, 2009, pp. 107-110
Bioline Code: np09018
Full paper language: English
Document type: Research Article
Document available free of charge

Nigerian Journal of Physiological Sciences, Vol. 24, No. 2, 2009, pp. 107-110

 en Hexamethonium produces both twitch and tetanic depression without fade in common African toad ( Bufo regularis check for this species in other resources )
Ajibola, E. S.; Adebayo, A. O.; Thomas, F. C.; Rahman, S. A.; Gbadebo, A. M. & Odunbaku, T. A.

Abstract

The study was designed to investigate the nature of the cholinoceptors at the sciatic nerve-gastrocnemius muscle junction of the common African toad (Bufo regularis). Using myographic technique, the twitch properties of the sciatic-gastrocnemius muscle preparation of the common African toad was studied. Both the twitch height and peak tetanic height were measured as a percentage of control. Hexamethonium at a concentratration of 0.1mM significantly (P<0.05) reduced the mean twitch height from 2.62cm to 1.0cm and mean peak tetanic height from 5.38cm to 4.32cm. Hexamethonium, however does not produce tetanic fade at the same concentration.We hypothesized that the cholinoceptors of the neuromuscular junction of the common African toad (Bufo regularis) resemble the developing synapse of African clawed toad ( Xenopus laevis check for this species in other resources ) and may contain muscarinic M1 autoreceptors at the pre juntional membrane.

Keywords
Hexamethonium, Tetanic fade, Bufo regularis, Cholinoceptors

 
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