Medicinal properties of fractionated acetone/water neem (Azadirachta indica) leaf extract from Nigeria: A review

The global scenario is now supporting the development of modern drugs from less toxic plant products with proven medicinal properties. Each part of neem plant (Azadirachta indica A. Juss) reportedly has various medicinal properties and has been in use in many continents for centuries. Recently, a fractionated neem-leaf extract known as IRAB with reported activities against Malaria, HIV/AIDS and cancer has been developed into a drug and currently marketed in Nigeria as IRACAP ®. This paper reviews the medicinal properties, clinical studies and safety concerns of this fractionated acetone-water neem leaves extract as a footstep to further studies both on the extract and/or its chemical constituents.