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Effects of Selenium Yeast on Blood Glucose and Antioxidant Biomarkers in Cholesterol Fed Diet Induced Type 2 Diabetes Mellitus in Wistar Rats.
Tanko, Y.; Jimoh, A.; Ahmed, A.; Adam, A.; Ejeh, L.; Mohammed, A. & Ayo, J. O.
Abstract
Summary: Selenium is an antioxidant that prevents oxygen radical from damaging cells from chronic diseases that can
develop from cell injury and inflammation such as diabetes mellitus. The aim of the study is to investigate the possible
protective effect of selenium yeast on cholesterol diet induced type-2 diabetes mellitus and oxidative stress in rats. Twenty
male wistar rats were divided in to four groups of five animals each: Group 1: (Negative control) received standard animal
feed only, Group 2: received cholesterol diet (CD) only, Group 3: received CD and 0.1 mg/kg selenium yeast orally, Group
4: Received CD and 0.2 mg/kg selenium yeast orally for six weeks. At the end of the study period, the animals were sacrificed
and the serum samples were collected and evaluated for estimation of antioxidant enzymes such as superoxide dismutase
(SOD), catalase (CAT) and glutathione peroxidase (GPx). The results showed a significant (P < 0.05) decrease in blood
glucose level in the groups co-administered CD and selenium yeast when compared to CD group only. Antioxidant enzymes
status recorded significant (P < 0.05) decrease in SOD, CAT and GPx activities in CD and selenium yeast administered when
compared to CD group only. In Conclusion, Selenium yeast administrations prevent free radical formations which are potent
inducer of diabetes mellitus.
Keywords
Cholesterol diet; Diabetes Mellitus; Selenium yeast; SOD; CAT; GPx
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