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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 95, No. 1, 2000, pp. 89-94
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Bioline Code: oc00014
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 95, No. 1, 2000, pp. 89-94
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Frequency of Specific anti-Toxoplasma gondii lgM, lgA and IgE in Colombian Patients with Acute and Chronic Ocular Toxoplasmosis
Jorge Enrique Gómez-Marin; Maria Teresa Montoya-de-Londoño; Jhon Carlos Castaño-Osorio; Fernando Alvarado Heine; Ana Maria Duque; Cathy Chemla; Dominique Aubert; Annie Bonhomme & Jean Michel Pinon
Abstract
We studied the frequency of specific anti-Toxoplasma IgM, IgA and IgE antibodies in serum of 28 immunocompetent Colombian patients, selected by ophthalmologists and with lesions that were compatible with ocular toxoplasmosis. Patients were classified in three groups: (i) group 1 consisted of ten patients with a first episode; (ii) group 2 with seven patients with a recurrence and (iii) group 3, consisted of eleven patients with chronic chorioretinal lesion without uveitis. We found that 10/28 (35%) of Colombian
patients with ocular toxoplasmosis possessed at least one serological marker for Toxoplasma infection different from IgG. In group 1 (first episode), we found simultaneous presence of specific IgM plus IgA plus IgE in 1/10 (10%). In group 2 (recurrences) in 1/7(14%) we found IgM and IgA test positives and in 1/7(14%) we found IgM and IgE tests positives. In group 3 (toxoplasmic chorioretinal scar) the IgA serological test was positive in 2/11(18%). These results show that serum IgM or IgA or IgE can be
present during recurrences.
Keywords
toxoplasmosis - human ocular toxoplasmosis - IgG - IgM - IgA IgE
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