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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 100, No. s1, 2005, pp. 121-125
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Bioline Code: oc05038
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 100, No. s1, 2005, pp. 121-125
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Mast cell changes in experimental diabetes: focus on attenuation of allergic events
Vinicius F Carvalho; Emiliano O Barreto; Renato SB Cordeiro; Vincent Lagente; Marco A Martins & Patrícia MR e Silva
Abstract
The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other. This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the consequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.
Keywords
diabetes - allergy - mast cells - glucocorticoids
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