
|
Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 105, No. 1, 2010, pp. 1-12
|
Bioline Code: oc10001
Full paper language: English
Document type: Review Article
Document available free of charge
|
|
Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 1, 2010, pp. 1-12
en |
Transmission blocking vaccines to control insect-borne diseases - A Review
Coutinho-Abreu, Iliano V & Ramalho-Ortigao, Marcelo
Abstract
Insect-borne diseases are responsible for severe mortality and morbidity worldwide. As control of insect vector
populations relies primarily on the use of insecticides, the emergence of insecticide resistance as well to unintended
consequences of insecticide use pose significant challenges to their continued application. Novel approaches to reduce
pathogen transmission by disease vectors are been attempted, including transmission-blocking vaccines (TBVs)
thought to be a feasible strategy to reduce pathogen burden in endemic areas. TBVs aim at preventing the transmission
of pathogens from infected to uninfected vertebrate host by targeting molecule(s) expressed on the surface of
pathogens during their developmental phase within the insect vector or by targeting molecules expressed by the vectors.
For pathogen-based molecules, the majority of the TBV candidates selected as well as most of the data available
regarding the effectiveness of this approach come from studies using malaria parasites. However, TBV candidates
also have been identified from midgut tissues of mosquitoes and sand flies. In spite of the successes achieved in the
potential application of TBVs against insect-borne diseases, many significant barriers remain. In this review, many
of the TBV strategies against insect-borne pathogens and their respective ramification with regards to the immune
response of the vertebrate host are discussed.
Keywords
transmission-blocking vaccines - insect and vector-borne disease
|
|
© Copyright 2010 - Instituto Oswaldo Cruz - Fiocruz Alternative site location: http://memorias.ioc.fiocruz.br
|
|