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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 110, No. 8, 2015, pp. 956-965
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Bioline Code: oc15130
Full paper language: English
Document type: Review Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 8, 2015, pp. 956-965
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Exploring the environmental diversity of kinetoplastid flagellates in the high-throughput DNA sequencing era
d’Avila-Levy, Claudia Masini; Boucinha, Carolina; Kostygov, Alexei; Santos, Helena Lúcia Carneiro; Morelli, Karina Alessandra; Grybchuk-Ieremenko, Anastasiia; Duval, Linda; Votýpka, Jan; Yurchenko, Vyacheslav; Grellier, Philippe & Lukeš, Julius
Abstract
The class Kinetoplastea encompasses both free-living and parasitic species from a wide range of hosts. Several
representatives of this group are responsible for severe human diseases and for economic losses in agriculture and
livestock. While this group encompasses over 30 genera, most of the available information has been derived from
the vertebrate pathogenic genera Leishmania and Trypanosoma. Recent studies of the previously neglected groups
of Kinetoplastea indicated that the actual diversity is much higher than previously thought. This article discusses the
known segment of kinetoplastid diversity and how gene-directed Sanger sequencing and next-generation sequencing
methods can help to deepen our knowledge of these interesting protists.
Keywords
Kinetoplastea; metagenomics; metabarcoding; taxonomy; Trypanosomatida
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