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Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample
Brochado, Maria José Franco; Gatti, Maria Fernanda Chociay; Zago, Marco Antônio & Roselino, Ana Maria
Abstract
Natural resistance-associated macrophage protein 1/solute carrier family 11 member 1 gene (Nramp1/Slc11a1)
is a gene that controls the susceptibility of inbred mice to intracellular pathogens. Polymorphisms in the human Slc11a1/Nramp1 gene have been associated with host susceptibility to leprosy. This study has evaluated nine polymorphisms
of the Slc11a1/Nramp1 gene [(GT)n, 274C/T, 469+14G/C, 577-18G/A, 823C/T, 1029 C/T, 1465-85G/A, 1703G/A,
and 1729+55del4] in 86 leprosy patients (67 and 19 patients had the multibacillary and the paucibacillary clinical
forms of the disease, respectively), and 239 healthy controls matched by age, gender, and ethnicity. The frequency
of allele 2 of the (GT)n polymorphism was higher in leprosy patients [p = 0.04, odds ratio (OR) = 1.49], whereas
the frequency of allele 3 was higher in the control group (p = 0.03; OR = 0.66). Patients carrying the 274T allele (p
= 0.04; OR = 1.49) and TT homozygosis (p = 0.02; OR = 2.46), such as the 469+14C allele (p = 0.03; OR = 1.53) of
the 274C/T and 469+14G/C polymorphisms, respectively, were more frequent in the leprosy group. The leprosy and
control groups had similar frequency of the 577-18G/A, 823C/T, 1029C/T, 1465-85G/A, 1703G/A, and 1729+55del4
polymorphisms. The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 were associated
with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated
with susceptibility and protection to leprosy, respectively.
Keywords
Slc11a1/Nramp1; leprosy; polymorphism
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