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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 111, No. 3, 2016, pp. 174-180
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Bioline Code: oc16025
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 3, 2016, pp. 174-180
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CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study
Santos, Erinaldo Ubirajara Damasceno dos; Lima, Géssica Dayane Cordeiro de; Oliveira, Micheline de Lucena; Heráclio, Sandra de Andrade; Silva, Hildson Dornelas Angelo da; Crovella, Sergio; Maia, Maria de Mascena Diniz & Souza, Paulo Roberto Eleutério de
Abstract
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia
(CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) and CCR5-Δ32 (rs333)
polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping
of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms
were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals
carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for
cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002),
while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus
(HPV) type, patients carrying the CCR2-64I polymorphism were protected against infection by HPV type 16 (OR =
0.35, p = 0.0184). In summary, our study showed a protective effect of CCR2-64I rs1799864 polymorphism against the
development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.
Keywords
chemokine receptors; cervical intraepithelial neoplasia; cervical cancer; single nucleotide polymorphism
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