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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 111, No. 11, 2016, pp. 712-716
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Bioline Code: oc16114
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 11, 2016, pp. 712-716
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Immune response in hamsters immunised with a recombinant fragment of LigA from Leptospira interrogans , associated with carrier molecules
Oliveira, Thaís L; Bacelo, Kátia L; Schuch, Rodrigo A; Seixas, Fabiana K; Collares, Tiago; Rodrigues, Oscar ED; Vargas, Josimar; Nascimento, Rafaella O do; Dellagostin, Odir A & Hartwig, Daiane D
Abstract
Immunisation with the C-terminal region of leptospiral immunoglobulin-like A protein (LigANI) has shown
promising results against leptospirosis. We evaluated the humoral immune response and protection induced by
LigANI associated with carboxyl multi-walled carbon nanotubes (COOH-MWCNTs), CpG oligodeoxynucleotides
(CpG ODNs), or Alhydrogel. Animals immunised with CpG ODNs were unable to develop a humoral immune response,
whereas immunisation with LigANI and COOH-MWCNTs produced a high level of IgG antibodies, similar
to that with LigANI and Alhydrogel, but it was not protective. The use of carbon nanotubes as an adjuvant in subunit
vaccines against leptospirosis is a novel approach for improving specific IgG production.
Keywords
Leptospira; LigANI; carrier molecules
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