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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 3, 2017, pp. 209-213
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Bioline Code: oc17027
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 3, 2017, pp. 209-213
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Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies
Cruz, Helena Medina; Scalioni, Leticia de Paula; Paula, Vanessa Salete de; Miguel, Juliana Custódio; Ó, Kycia Maria Rodrigues do; Milagres, Flavio Augusto Pádua; Cruz, Marcelo Santos; Bastos, Francisco Inácio; Flores, Priscila Pollo; Leal, Erotildes; Motta-Castro, Ana Rita Coimbra; Lewis-Ximenez, Lia Laura; Lampe, Elisabeth & Villar, Livia Melo
Abstract
Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV).
This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different
Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low
resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™
RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were
50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII
and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for
screening in regions endemic for HBV.
Keywords
hepatitis B virus; antibodies; rapid tests; performance
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