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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 173-182
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Bioline Code: oc97183
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 173-182
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Human Eosinophil-lymphocyte Interactions
Weller, Peter F. & Lim, Kaiser
Abstract
While the eosinophil's effector functions clearly can contribute to the
pathogenesis of allergic diseases, the evolutionary benefit to having
eosinophils as a distinct class of leukocytes is not clear, especially if
one must reconsider the nominally beneficial role of eosinophils in
parasite host defense. Eosinophils are equipped to respond to lymphocytes
and their cytokines (and not solely the eosinophil growth factor
cytokines), but the functional consequences of such eosinophil responses
need to be defined. Conversely, eosinophils, as antigen-presenting cells
(APCs) or sources of lymphocyte-active cytokines, may stimulate and effect
lymphocyte functioning. Eosinophils share with CD4+ lymphocytes expression
of a number of receptors, including CD4 and IL-2R, and specific a4
integrins that may help in their common recruitment and activation.
Further, elucidation of the interactions between lymphocytes and
eosinophils will contribute to a broader understanding of the functioning
of eosinophils in "normal" ongoing immune responses and in allergic
disorders.
Keywords
human eosinophil - lymphocite interactions - allergic disorders
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