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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 219-222
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Bioline Code: oc97191
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 219-222
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Antigen-induced Pleural Eosinophilia Is Suppressed In Diabetic Rats: Role Of Corticosteroid Hormones
Diaz, Bruno L.; Serra, Magda F.; Barreto, Emiliano O.; Cordeiro, Renato S.B.; Martins, Marco A. & E Silva, Patricia M.R.
Abstract
Previous studies have evidenced for the existence of interactive
regulatory mechanisms between insulin and steroid hormones in different
systems. In this study, we have investigated whether endogenous
corticosteroids could be implicated in the hyporeactivity to antigen
challenge observed in sensitized diabetic rats. Alloxinated rats showed a
long-lasting increase in the blood glucose levels and a reduction in the
number of pleural mast cells at 48 and 72 hr, but not at 24 hr after
alloxan administration. In parallel, they also showed a significant
elevation in the plasma levels of corticosterone together with an increase
in the adrenal/body weight ratio. Antigen-evoked eosinophil accumulation
appeared significantly reduced in rats pretreated with dexamethasone as
well as in those rendered diabetic 72 hr after alloxan. In the same way,
naive animals treated with dexamethasone also responded with a significant
decrease in the number of pleural mast cells. Interestingly, when
sensitized diabetic rats were pretreated with the steroid antagonist RU
38486 a reversion of the reduction in the allergen-induced eosinophil
accumulation was noted. We conclude that the down-regulation of the
allergic inflammatory response in diabetic rats is close-related to
reduction in mast cell numbers and over expression of endogenous
corticosteroids.
Keywords
diabetes - allergic pleurisy - mast cells - eosinophils - corticosteroids
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