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Surfactant Effects on Mortality and Morbidity of Respiratory Distress Syndrome in Neonates
Kamrani, Kamyar; Kalmarzi, Rasool Nasiri & Sotoudeh, Kambiz
Abstract
Objective:
The purpose of this study was to compare the mortality and morbidity rates of neonatal
respiratory distress syndrome (RDS) treated with and without surfactant in ventilated patients.
Methods:
In this descriptive-analytical study, the morbidity and mortality rates of RDS in 50
patients of the study group treated with surfactant were compared with 66 patients of control group
treated without surfactant. The children of the control group received treatment at a time when
surfactant was not available in market. Surfactant was used as Survanta during the first 24 hours of
life with a dose of 4 ml/kg in four different positions through tracheal tube only once.
Findings:
The two groups were comparable in baseline parameters including birth weight, sex,
gestational age and primary diagnosis. Mortality reduced significantly. There were no differences
in the incidence of severe complications including, intraventricular hemorrhage and patent ductus
arteriosus, but pneumothorax, sepsis and pulmonary hemorrhage occurred more common in the
control group.
Conclusion:
Use of surfactant in neonatal respiratory distress syndrome significantly decreased
mortality, pneumothorax, sepsis and pulmonary hemorrhage.
Keywords
Prematurity; Respiratory Distress syndrome; Surfactant; Neonate
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