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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 22, No. 3, 2012, pp. 297-302
Bioline Code: pe12055
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 22, No. 3, 2012, pp. 297-302

 en Beta Globin Frameworks in Thalassemia Major Patients from North Iran
Akhavan-Niaki, Haleh; Banihashemi, Ali & Azizi, Mandana


Objective: Four combinations of five neutral sequence changes at rs713040, rs10768683, rs7480526, rs7946748, and rs1609812 occurring in the human beta globin gene defined as frameworks have been reported in beta globin gene. Here we report for the frequency of these frameworks in thalassemia major patients of North Iran.
Methods: Beta globin gene frameworks of 46 thalassemia major patients of North Iran were determined using Denaturing Gradient Gel Electrophoresis.
Findings: All these frameworks called framework 1, 2, 3, 3a were present at the frequency of 23.9%, 45.7%, 6.5% and 23.9% respectively.
Conclusion: These frameworks may be used for tracking mutant alleles in prenatal diagnosis programs.

Beta–Globin; Thalassemia; Polymorphism; Denaturing Gradient Gel Electrophoresis

© Copyright 2012 - Iranian Journal of Pediatrics
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