Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 22, No. 3, 2012, pp. 412-416
Bioline Code: pe12074
Full paper language: English
Document type: Case Report
Document available free of charge
Iranian Journal of Pediatrics, Vol. 22, No. 3, 2012, pp. 412-416
© Copyright 2012 - Iranian Journal of Pediatrics
Congenital Insensitivity to Pain and Anhydrosis (CIPA) Syndrome; A Report of 4 Cases|
Daneshjou, Khadije; Jafarieh, Hanieh & Raaeskarami, Seyed-Reza
Background: Background: Congenital insensitivity to pain with anhidrosis (CIPA) is characterized by
recurrent episodes of infections and unexplained fever, anhidrosis (inability to sweat), and absence of
reaction to noxious stimuli, self-mutilating behavior, mental retardation and damages to oral structures.
Case Presentation: In this article, we have demonstrated the signs and symptoms of 4 children that refer to
the pediatrics department of the Imam Khomeini hospital and assay about their complications with this
disease. They mostly presented by recurrent osteomyelitis in their feet that severely controlled by antibiotic
therapy and even surgery. They had no pain sensation in spite of deep sore and infection.
Conclusion: This syndrome can be diagnosed by clinical and paraclinical tests together but it would be better
to confirm by genetic test. The diagnosis of this syndrome helps us to try for the better quality of life for the
patients and avoid unnecessary amputations.
CIPA Syndrome; Congenital Pain Insensitivity; Congenital Analgesia; Osteomyelitis
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