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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406 EISSN: 1018-4406
Vol. 23, No. 2, 2013, pp. 131-137
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Bioline Code: pe13024
Full paper language: English
Document type: Research Article
Document available free of charge
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Iranian Journal of Pediatrics, Vol. 23, No. 2, 2013, pp. 131-137
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The Investigation of Effects of Blood Exchange Transfusion on Selenium in Newborn Infants by Instrumental Neutron Activation Analysis Method
Khatami, Seyedeh-Fatemeh; Parvaresh, Pouya; Parvaresh, Parviz & Gharib, Morteza
Abstract
Objective: The evidence for the effects of blood exchange transfusion on selenium (Se) in newborn infants is
unknown. This study was conducted to determine the possible effects of blood exchange transfusion on Se by
comparing the Se blood concentrations before and after exchange transfusion in jaundiced neonates.
Methods: A total of 30 jaundiced term neonates who underwent blood exchange transfusion (EXT) for first
time because of idiopathic unconjugated hyperbilirubinemia, were recruited. The Se level of 30 blood bank
donors' samples used for EXT were measured and 30 pairs of uncontaminated umbilical cord blood samples
were investigated for Se before and after exchange transfusion. The samples were analyzed by instrumental
neutron activation analysis method. Serum bilirubin concentrations were measured by venous blood samples
before EXT.
Findings: The average of Se concentration before EXT was higher than that after EXT (629.78±283.82 SD ppb
versus 454.83±213.75 SD ppb) (P<0.05). There was significant correlation between the blood concentration
of Se before and after EXT and also between the blood level of Se before EXT and total serum bilirubin level
(P<0.05). There was no significant correlation between the blood concentration of Se before EXT and babies' gender and weight (P>0.05). The average Se level in samples obtained from transfused blood products was
507.90±223.56 SD ppb.
±Conclusion: Blood exchange transfusion caused a 28% decrease of the blood Se level because the blood
donors had lower blood Se levels than the newborns. Furthermore, there was a significant correlation
between the blood level of Se before EXT and the total serum bilirubin level.
Keywords
Trace elements; Exchange transfusion; Newborn; Neutron activation analysis; Selenium
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© Copyright 2013 - Iran Journal of Pediatrics Alternative site location: http://diglib.tums.ac.ir/pub/
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