Objective: We examined the preventive effect of probiotic and antibiotics versus antibiotics alone, in children
with recurrent urinary tract infections (RUTI) in a preliminary randomized clinical trial.
Methods: Between March 2007 and April 2011, children with the history of RUTI and unilateral
vesicoureteral reflux (VUR) were randomly assigned to receive concomitant probiotic and antibiotics
(
Lactobacillus acidophilus
and
bifidobacterium lactis
, 10
7/ml, as 0.25 ml/kg three times a day regimen in
addition to Nitrofurantoin, 1mg/kg daily (group I). In group II, all children received conventional prophylactic
antibiotics alone (Nitrofurantoin, 1 mg/kg daily). Randomization was performed via using the random
numerals table in a 1:1 manner with stratification by sex, age and grade of reflux. The urine examinations
were done monthly and the incidence of UTI was evaluated in these two groups.
Findings: Forty-one children (age: 8.3±3.1 years) in group I and 44 children (age: 8.0±3.0 years) in group II
were compared. During the course of three years, 39% in group I and 50% of participants in group II
experienced RUTIs (
P=0.4). Incidences of UTI - febrile and afebrile - reduced in both groups without any
significant differences after two years of prophylaxis. Also, incidence of afebrile UTIs did not significantly
differ (0.51±1.30 and 0.81±1.41 respectively,
P=0.3); however, the incidence of febrile UTIs in particular were
lower in group I (0.00±0.00 versus 0.13±0.40,
P=0.03) in the last year.
Conclusion: The consumption of probiotic and antibiotics in children with RUTI is safe and more effective in
reducing the incidence of febrile UTI in comparison to prophylactic antibiotics alone.
