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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406 EISSN: 1018-4406
Vol. 23, No. 4, 2013, pp. 439-444
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Bioline Code: pe13083
Full paper language: English
Document type: Research Article
Document available free of charge
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Iranian Journal of Pediatrics, Vol. 23, No. 4, 2013, pp. 439-444
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Outcome of Vesicoureteral Reflux in Infants: Impact of Prenatal Diagnosis
Mohammadjafari, Hamid; Alam, Alireza; Mohammadi, Saeed; Mousavi, Seyed-Abdollah; Kosaryan, Ahmadshahab; Khademloo, Mohammad & Abedi, Mohammad
Abstract
Objective: Vesicoureteral reflux (VUR) is an important disorder that could be diagnosed in antenatal or
postnatal period. The natural history of VUR seems to be different between prenatal or postnatal forms of the
disease. We compared the natural history and outcome of vesicoureteral reflux in infants less than one year
old diagnosed prenatally or postnatally.
Methods: All infants less than 12 months old with VUR were enrolled in two groups. Group 1 composed of
patients with antenatal hydronephrosis and group2, infants with diagnosis of VUR because of UTI or other
postnatal problems. We followed patients for an average of 33 months. Outcome was assessed by several
factors: somatic growth, need for surgery, resolution, occurrence of UTI and scar formation.
Findings: We studied 236 renal units in 152 patients (70 boys, 82girls), 67 patients in group 1 and 85 patients
in group2. Occurrence of recurrent UTI was 10.6% with no significant difference between two groups. Reflux
resolved in postnatal group more significantly than in the other group (73% vs 49%). Scar developed
similarly in both groups (15% vs 25% of renal units). Surgery performed in 7 (8.2%) of postnatal and 4 (6%)
of prenatal group with no significant differences between the two groups.
Conclusion: VUR diagnosed prenatally has similar importance and outcome as postnatal diagnosed one. We
suggest performing the same imaging and treatment procedures for prenatally and postnatally diagnosed
VUR.
Keywords
Vesicoureteral Reflux; Hydronephrosis; Urinary Tract Infection; Renal Scaring; Prenatal Diagnosis
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© Iranian Journal of Pediatrics Alternative site location: http://diglib.tums.ac.ir/pub/
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