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Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report
Miri-Aliabad, Ghasem; Sadat-Hosseini, Maryam & Dorgalaleh, Akbar
Abstract
Fanconi syndrome is a metabolic disorder involving dysfunction of the renal proximal tubules, resulting in excessive urinary excretion
of several metabolites. Various factors may lead to Fanconi syndrome, as it may be a genetic disease with primary or secondary
etiologies, or may be acquired. In this study, we report a unique case of Fanconi syndrome with development of a relatively rare
acute leukemia, a condition that has not been reported before. The case was an 8-year-old boy with familial occurrence of Fanconi
syndrome, presenting with pallor, asthenia, recurrent infections, growth failure, and a variety of biochemical and hematological
abnormalities. After physical examination, radiographic studies, and comprehensive laboratory analyses, Fanconi syndrome associated
with bilineal acute leukemia, of myeloid and T-lymphoid lineages, was diagnosed.
Keywords
Fanconi Syndrome; Renal Dysfunction; Bilineal Leukemia
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