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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406 EISSN: 1018-4406
Vol. 26, No. 6, 2016, pp. 1-3
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Bioline Code: pe16086
Full paper language: English
Document type: Case Report
Document available free of charge
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Iranian Journal of Pediatrics, Vol. 26, No. 6, 2016, pp. 1-3
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Pulmonary Spread of Juvenile Laryngeal Papillomatosis: A Case Report
Li, Chen-Long & Zhang, Tian-Yu
Abstract
Introduction: Recurrent respiratory papillomatosis (RRP) is usually a relatively benign disease but can have an aggressive clinical
course. The primary treatment for laryngeal papillomatosis is endoscopic resection. However, there is no effective treatment for
pulmonary spread of laryngeal papillomatosis.
Case Presentation:We describe a rare case of a 19-year-old man with pulmonary spread of laryngeal papillomatosis. The treatment
regimen was surgical resection under general anesthesia using suspension laryngoscopy and endoscopy. The patient had been diagnosed
with laryngeal papillomatosis and had undergone a tracheotomy when he was 18 months old. He underwent 17 endoscopic
resections for laryngeal papillomatosis at intervals of 3 months to 1 year. At follow-up, the patient continued to have tracheal intubation
and was not extubated. CT scans revealed multiple nodular and cavitary lesions in both lungs. Laryngoscopy performed when
the patient was 18 years showed diffuse papillomata in the glottis and left ventricular fold.
Conclusions: This article presents a rare case of juvenile laryngeal papillomatosis associated with the human papilloma virus (HPV)
HPV-11 and pulmonary spread. Intravenous cidofovir has oncogenic potential, but it has been used successfully to treat five patients
with pulmonary spread of RRP. Intravenous cidofovir should be considered as salvage therapy.
Keywords
Recurrent Respiratory Papillomatosis; Laryngeal Tumors; Pulmonary Spread; Cidofovir
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© Copyright 2016 - Growth & Development Research Center Alternative site location: http://diglib.tums.ac.ir/pub/
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