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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 36, No. 5, 2004, pp. 303-305
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Bioline Code: ph04102
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 36, No. 5, 2004, pp. 303-305
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The hepatotoxic effect of halofantrine in guinea pigs
Obi E, Orisakwe OE, Asomugha LA, Udemezue OO, Orish VN
Abstract
OBJECTIVE:
To investigate the hepatotoxic effects of halofantrine in guinea pigs.
MATERIAL AND METHODS:
Halofantrine (30-105 mg/kg) was administered orally to three groups of guinea pigs thrice a week for 4 weeks. One group of animals which received distilled water served as control. The relative weight of the liver was measured. The biochemical parameters like alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and also total and conjugated bilirubin were measured. Liver tissues were subjected to histopathological examination.
RESULTS:
There was a significant (P<0.05) increase in the relative weight of the liver in all the treated groups compared to control. There was also a significant (P<0.05) increase in all the liver enzymes and total and conjugated bilirubin. Histopathological examination of the liver revealed moderate portal triaditis to severe hepatic degeneration in the halofantrine-treated groups.
CONCLUSION:
Halofantrine exhibits hepatotoxic effect in guinea pigs.
Keywords
Antimalarial, live functions, liver damage
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© Copyright 2004 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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