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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 41, No. 1, 2009, pp. 28-31
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Bioline Code: ph09007
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 41, No. 1, 2009, pp. 28-31
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Anti-stress activity of hydro-alcoholic extract of Eugenia caryophyllus buds (clove)
Singh, Anand Kumar; Dhamanigi, Sunil S & Asad, Mohammed
Abstract
Objective: The present study was undertaken to evaluate the anti-stress effect of the hydro-alcoholic extract of clove.
Methodology: The anti-stress effect was evaluated on cold restraint induced gastric ulcers, sound stress induced biochemical changes and anoxic stress induced convulsions. Clove extract was administered orally at two different doses of 100 and 200 mg/kg. Zeetress, a known anti-stress formulation (14 mg/kg p.o) was used as the standard drug.
Results: Both the doses of clove extract showed good anti-stress effect in all the tested models. The clove extract reduced the development of cold restraint induced gastric ulcers and prevented the biochemical changes induced by sound stress such as increase in plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, glucose, cholesterol and corticosterone. Clove extract was also effective in increasing the latency of anoxic stress induced convulsions in mice.
Conclusion: The hydro-alcoholic extract of clove at doses of 100 and 200 mg/kg orally possesses good anti-stress activity.
Keywords
Anoxic stress, anti-stress, cold restraint, eugenia caryophyllus, sound stress
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© Copyright 2009 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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